Structure of piperidinoethyl esters of alkoxyphenylcarbamic acids and their thermodynamic parameters |
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Authors: | M H Umbreit J Cicmárik P Nowicki |
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Institution: | (1) Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, K. Marcinkowski University of Medical Sciences in Poznan, ul. Grunwaldzka 6, 60-780 Poznan, Poland;(2) Department of Pharmaceutical Chemistry, Pharmaceutical Faculty, ul. Odbojarov 10, 832-32 Bratislava 3, Slovakia |
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Abstract: | The melting temperature of nine piperidinoethyl esters of alkoxyphenylcarbamic acid (hexaoxy-octyloxy) including all site
isomers was investigated. The analyses were performed using DSC apparatus, sample mass ranged from 0.2 to 2.5 mg, heating
rate was 5 K min-1 and in static air atmosphere. On the basis of melting peak, thermodynamic figures like: enthalpy, entropy, height and area
of the peak and temperature of the partial peak were fixed. For evaluation of the results Principal Component Analysis was
applied. Thanks to this method the influence of length (mass) and position of alkoxy substituents on the thermodynamic parameters
of melting of compounds under investigation were determined.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | principal component analysis melting peak DSC piperidinoethyl esters of alkoxyphenylcarbamic acid melting point |
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