| 生物化学中酶促"不可逆"反应及其相关问题辨析 |
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| 引用本文： | 马新雨,王志鹏,田杰,蒋振雄,姜汉杰,孙鹤,周青璇,王鑫.生物化学中酶促"不可逆"反应及其相关问题辨析[J].大学化学,2019,34(4):77-83. |
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| 作者姓名： | 马新雨 王志鹏 田杰 蒋振雄 姜汉杰 孙鹤 周青璇 王鑫 |
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| 作者单位： | Department of Chemistry, Texas A&M University, College Station, TX 77840, USA;Department of Chemistry, Texas A&M University, College Station, TX 77840, USA;Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;Department of Biology, Texas A&M University, College Station, TX 77840, USA;Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;南方科技大学化学系,广东深圳,518055;Broad Institute of MIT and Harvard, Cambridge, Department of Medicine, Harvard Medical School, Renal Division, Brigham and Women's Hospital, Boston, MA 02142, USA;Department of Microbiology, Miami University, Oxford, OH 45056, USA |
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| 摘 要： | 在生物化学教学和研究中,一些酶促反应被归类为不可逆反应。然而,此处的"不可逆"与物理化学中的"不可逆"有所不同,这一表述本身常导致学生的困惑。不仅如此,"不可逆"的实际含义及其衍生的观念可能进一步使学生产生很多对基本生化反应过程的严重误解。本文以物理化学所定义的"不可逆"为准,重新讨论生物化学中所指"不可逆"的准确含义,并举例讨论了包括"速控步""限速酶""高能磷酸键"在内的若干因生物化学中"不可逆"的不准确定义造成的认知误区。
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| 关 键 词： | 酶促反应 可逆反应 化学平衡 |
| 收稿时间： | 2018-06-15 |
Discussion on the Definition of "Irreversible" Reactions and Its Related Concepts in Biochemistry |
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| Xinyu MA,Zhipeng A. WANG,Jie TIAN,Zhenxiong JIANG,Hanjie JIANG,He SUN,Qingxuan ZHOU,Xin WANG.Discussion on the Definition of "Irreversible" Reactions and Its Related Concepts in Biochemistry[J].University Chemistry,2019,34(4):77-83. |
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| Authors: | Xinyu MA Zhipeng A WANG Jie TIAN Zhenxiong JIANG Hanjie JIANG He SUN Qingxuan ZHOU Xin WANG |
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| Abstract: | |
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| Keywords: | Enzyme catalysis Reversible reaction Chemical equilibrium |
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