Extractive Atmospheric Pressure Photoionization (EAPPI) Mass Spectrometry: Rapid Analysis of Chemicals in Complex Matrices |
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| Authors: | Chengyuan Liu Jiuzhong Yang Jian Wang Yonghua Hu Wan Zhao Zhongyue Zhou Fei Qi Yang Pan |
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| Institution: | 1.National Synchrotron Radiation Laboratory,University of Science and Technology of China,Hefei,China;2.Research and Development Centre,China Tobacco Anhui Industrial Co., Ltd.,Hefei,China;3.Power Machinery and Engineering of Ministry of Education,Shanghai Jiao Tong University,Shanghai,China |
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| Abstract: | Extractive atmospheric pressure photoionization (EAPPI) mass spectrometry was designed for rapid qualitative and quantitative analysis of chemicals in complex matrices. In this method, an ultrasonic nebulization system was applied to sample extraction, nebulization, and vaporization. Mixed with a gaseous dopant, vaporized analytes were ionized through ambient photon-induced ion–molecule reactions, and were mass-analyzed by a high resolution time-of-flight mass spectrometer (TOF-MS). After careful optimization and testing with pure sample solution, EAPPI was successfully applied to the fast screening of capsules, soil, natural products, and viscous compounds. Analysis was completed within a few seconds without the need for preseparation. Moreover, the quantification capability of EAPPI for matrices was evaluated by analyzing six polycyclic aromatic hydrocarbons (PAHs) in soil. The correlation coefficients (R 2 ) for standard curves of all six PAHs were above 0.99, and the detection limits were in the range of 0.16–0.34 ng/mg. In addition, EAPPI could also be used to monitor organic chemical reactions in real time. |
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