| 酸催化的二芳基甲醇脱水环化氧化芳构化直接构筑4-芳基喹啉 |
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| 引用本文： | 魏钊,杨化萌,张金龙,蒋高喜.酸催化的二芳基甲醇脱水环化氧化芳构化直接构筑4-芳基喹啉[J].分子催化,2019,33(4):371-381. |
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| 作者姓名： | 魏钊 杨化萌 张金龙 蒋高喜 |
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| 作者单位： | 中国科学院兰州化学物理研究所 羰基合成与选择氧化国家重点实验室, 甘肃 兰州 730000;中国科学院大学, 北京 100049,中国科学院兰州化学物理研究所 羰基合成与选择氧化国家重点实验室, 甘肃 兰州 730000,中国科学院兰州化学物理研究所 羰基合成与选择氧化国家重点实验室, 甘肃 兰州 730000,中国科学院兰州化学物理研究所 羰基合成与选择氧化国家重点实验室, 甘肃 兰州 730000 |
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| 基金项目： | 中国科学院百人计划，国家自然科学基金（21602231），江苏省自然科学基金（BK20160396） |
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| 摘 要： | 我们发展了酸催化的二芳基甲醇的脱水环化氧化芳构化的方法，直接高产率（高达81%）的合成轴手性的4-芳基喹啉.而且，Lewis酸Zn（OTf）2和手性膦酸都能催化这个反应，初步的不对称研究可以用er 71：29得到产物.
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| 关 键 词： | 手性膦酸 轴手性 手性喹啉 |
| 收稿时间： | 2019/7/17 0:00:00 |
| 修稿时间： | 2019/7/30 0:00:00 |
Direct Construction of Axially Chiral 4-Arylquinoline via Acid-Promoted Dehydrative Cyclization/Oxidation of Diarylmethanols |
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| WEI Zhao,YANG Hua-meng,ZHANG Jin-long and JIANG Gao-xi.Direct Construction of Axially Chiral 4-Arylquinoline via Acid-Promoted Dehydrative Cyclization/Oxidation of Diarylmethanols[J].Journal of Molecular Catalysis (China),2019,33(4):371-381. |
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| Authors: | WEI Zhao YANG Hua-meng ZHANG Jin-long and JIANG Gao-xi |
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| Institution: | State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;University of Chinese Academy of Sciences, Beijing 100049, China,State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China,State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China and State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China |
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| Abstract: | Acid-promoted dehydrative cyclization/oxidation aromatization sequences from diarylmethanols was developed, providing a new family of axially chiral 4-arylquinolines in high yields (up to 81%). Importantly, both Lewis acid Zn(OTf)2 and organic chiral phosphoric acid (CPA) are able to catalyzed this transformation and the asymmetric version was also primary investigated (up to 71:29 er). |
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| Keywords: | chiral phosphoric acid axially chiral chiral quinoline |
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