| BoPhoz类膦-氨基膦配体在Rh-催化β-脱氢氨基酸酯的不对称氢化反应中的应用 |
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| 引用本文： | 胡向平.BoPhoz类膦-氨基膦配体在Rh-催化β-脱氢氨基酸酯的不对称氢化反应中的应用[J].分子催化,2011(6):485-488. |
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| 作者姓名： | 胡向平 |
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| 作者单位： | 中国科学院大连化学物理研究所 |
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| 摘 要： | 将BoPhoz类膦-氨基膦配体应用在Rh-催化β-脱氢氨基酸酯的不对称氢化反应中，考察了配体结构及反应条件对反应结果的影响，并在优化的条件下研究了各种底物的适用范围，产物的对映选择性达81％ee．
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| 关 键 词： | 膦-氨基膦配体 铑 氢化 不对称催化 β-脱氢氨基酸酯 |
| 收稿时间： | 2011/11/24 0:00:00 |
| 修稿时间： | 2011/11/24 0:00:00 |
Rh-Catalyzed Asymmetric Hydrogenation of beat-(Acylamino)acrylates with BoPhoz-type Ligands |
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| Abstract: | A series of BoPhoz-type phosphine-aminophosphine ligands were employed in the Rh-catalyzed asymmetric hydrogenation of beta-(acylamino)acrylates. The results indicated that the structure of BoPhoz-type ligands has a significant influence on this hydrogenation, and ligand 3c bearing bis(3,5-difluoro)phenyl]phosphinoamino moiety and bis(3,5-dimethyl)phenyl]- phosphino moiety showed the best enantioselectivity. Under the optimal conditions, a variety of beta-(acylamino)acrylates were hydrogenated in enantioselectivities of up to 81% ee. |
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| Keywords: | phosphine-aminophosphine ligands rhodium hydrogenation asymmetric catalysis beta-(acylamino)acrylate |
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