原位生成的水溶性Salen-Pd配合物催化微波促进水中的C-C偶联反应

将一种水溶性Salen，N，N’-双（5-磺酸基-2-羟基）苄基]缩N，N’-二甲基-1，2-乙二胺（L）与醋酸钯原位生成水溶性Salen-Pd配合物，该水溶性钯配合物应用于催化微波加热的水中的Heck和Sonogashira碳-碳偶联反应.在优化反应条件之后，对溴苯衍生物与乙烯衍生物的Heck偶联反应以及溴苯衍生物与苯乙炔及其衍生物之间的Sonogashira偶联反应进行了考察.发现，在优化的反应条件下，无论是Heck反应，还是Sonogashira偶联反应，都能得到很好的收率.在有机物分离之后，水相继续循环使用4次，在水相的前3次循环使用时，都获得了不错的收率.

Microwave-Promoted C-C Coupling Reactions in Water Catalyzed by Made in situ Water-Soluble Salen-Pd Complex

The water-soluble Salen-Pd complex was made in situ with mixture of N,N''-bis(5-sulfonato-2-hydroxy)benzyl]-N,N''-dimethyl-ethane-1,2-diaminen and palladium acetate in water. This complex was used as catalyst for microwave-promoted Heck and Sonogashira coupling reaction. Under the optimal reaction conditions, the Heck reaction of bromobenzene and its derivatives with ethylene derivatives, and the Sonogashira coupling reaction of bromobenzene''s derivatives with phenylacetylene and its derivatives, were investigated. It was found that under the optimal reaction conditions, the yields of both Heck reactions and Sonogashira coupling reactions were good to excellent. Under the same reaction condition, the aqueous phase was reused 4 times for Heck reactions and Sonogashira coupling reactions, And the results indicated that the aqueous phase still had good catalytic activity in the first three recycles.