Synthesis of marine guanidine alkaloids and their application as chemical/biological tools |
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Authors: | Nagasawa Kazuo Hashimoto Yuichi |
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Institution: | Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan. |
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Abstract: | Ptilomycalin A and crambescidins, novel marine guanidine alkaloids, have a unique pentacyclic guanidine structure, and exhibit a considerable array of biological activities. The first method developed for the synthesis of the pentacyclic guanidine core structure involved successive 1,3-dipolar cycloaddition reactions and resulted in the first total synthesis of crambescidin 359. The synthesis of other pentacyclic guanidine derivatives has been based on this methodology and applied as tools for studying biological activities, and as chemical reaction catalysts. |
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Keywords: | guanidine alkaloid crambescidin 359 Ca2+‐ATPase structure–activity relationship phase‐transfer catalyst |
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