非甾类抗炎性药物的吸附与分离分析

非甾类抗炎性药物(NSAIDs)以其良好的消炎、解热和止痛等作用,广泛应用于人类疾病的治疗中.非甾类药物参与炎症治疗的同时不能被肝脏完全代谢,大部分母体化合物及其代谢物随人体排出.大量数据表明,在环境中残留的药物会直接或间接的以食品安全问题呈现出来,这成为分析化学、材料化学等诸多领域学科重点研究课题之一.由于NSAIDs的样品基质复杂,待分析组分种类繁多,目标分析物含量低,分析人员往往借助一些样品前处理技术来对其进行吸附与分离分析.总结了近年来非甾类抗炎性药物所呈现的问题,以及目前对环境中NSAIDs的多种分离检测技术,分离检测的核心是萃取材料的选择,并综述了近年来相关对NSAIDs有效吸附分离材料的研究进展,以及对优异吸附分离材料的展望.

Adsorption and Separation of Non-Steroidal Anti- Inflammatory Drugs

Non-steroidal anti-inflammatory drugs(NSAIDs) are widely used in the treatment of human diseases because of their good anti-inflammatory, antipyretic and analgesic effects. These non-steroidal drugs that entered the human body cannot completely be metabolized by the liver during the treatment of inflammation and the rest of its metabolites excreted through the excretory system of body. Large amounts of data indicate that the residual drugs in the environment are directly or indirectly presented as food safety problems, therefore it becomes one of the main investigations in many fields, such as analytical chemistry and material chemistry. Sample pretreatment techniques are frequently used to carry out the adsorption and separation analysis due to the complexity of the sample matrix, the wide range of analytical components and the low content of the target analyte. In recent years the problems caused by non-steroidal anti-inflammatory drugs and the variety of analysis of the separation and detection techniques of the non-steroidal anti-inflammatory drugs mechanism for the environment are summarized. The core of separation and determination is the selection of extracting materials. The research progress on non steroidal anti-inflammatory drugs for the effective, outstanding adsorption and separation of materials are reviewed.