| 泛昔洛韦解离常数和结合常数的测定 |
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| 引用本文： | 陈毅挺,苏碧玲,黄 露,林 棋.泛昔洛韦解离常数和结合常数的测定[J].分析测试技术与仪器,2011,17(1):1-5. |
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| 作者姓名： | 陈毅挺 苏碧玲 黄 露 林 棋 |
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| 作者单位： | 闽江学院化学与化学工程系,福建,福州,350108 |
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| 基金项目： | 福建省青年人才创新项目，福建省教育厅科技项目，食品安全分析与检测教育部重点实验室(福州大学)开放课题，福建省高校杰出青年科研人才培育计划资助 |
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| 摘 要： | 采用紫外分光光度法,在225 nm与305 nm波长处测得泛昔洛韦的解离常数pKa均为3.8.在含有泛昔洛韦的pH值为7.0的Na2HPO4-KH2PO4缓冲溶液中加入牛血清白蛋白,以双倒数公式法测定二者的结合常数.结果表明,牛血清白蛋白与泛昔洛韦形成了1∶4的配合物,其结合常数是4.51×106 L/mol.方法简便,结果可靠。
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| 关 键 词： | 泛昔洛韦 紫外分光光度法 解离常数 牛血清白蛋白 结合常数 |
| 收稿时间： | 2010/10/25 0:00:00 |
| 修稿时间： | 2010/12/1 0:00:00 |
Determination of Dissociation Constant and Binding Constant of Famciclovir |
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| CHEN Yi-ting,SU Bi-ling,HUANG Lu and LIN Qi.Determination of Dissociation Constant and Binding Constant of Famciclovir[J].Analysis and Testing Technology and Instruments,2011,17(1):1-5. |
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| Authors: | CHEN Yi-ting SU Bi-ling HUANG Lu and LIN Qi |
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| Institution: | Chemistry and Chemical Engineering Department of Minjiang University, Fuzhou 350108, China;Chemistry and Chemical Engineering Department of Minjiang University, Fuzhou 350108, China;Chemistry and Chemical Engineering Department of Minjiang University, Fuzhou 350108, China;Chemistry and Chemical Engineering Department of Minjiang University, Fuzhou 350108, China |
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| Abstract: | Both the dissociation constants of famciclovir obtained were 3.8 using ultraviolet spectrophotometry with the wavelengths at 225 nm and 305 nm.Bovine serum albumin was added to a Na2HPO4-KH2PO4 buffer solution(pH 7.0) with famciclovir.The binding constant was measurd by the double-reciprocal analysis.The results showed that bovine serum albumin and famciclovir formed a 1∶4 complex,and the binding constant obtained was 4.51×106 L/mol.This method is simple and reliable. |
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| Keywords: | famciclovir ultraviolet spectrophotometry dissociation constant bovine serum albumin binding constant |
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