保健食品中非法添加物检测的前处理及分析方法研究进展

保健食品作为一种特定的食品种类，能调节人体的机能，适用于特定人群食用.但是在保健食品中添加化学药物和非法添加物的现象也层出不穷，因此迫切需要建立多指标的有效检测方法，为保健食品的质量安全提供技术保障.高效的前处理方法和高灵敏的分析方法为检测非法添加物提供了有效的技术手段.综述了近三年来溶剂萃取和固相萃取样品前处理方法，以及高效液相色谱、实时直接分析质谱、表面增强拉曼光谱及色谱-质谱串联技术等分析方法在微量及痕量非法添加物检测中的应用，为进一步研究建立高效简便的前处理方法和检测新方法、新技术提供理论参考.

Advances in Sample Pretreatment and Analytical Methods for Detection of Illegal Additives in Health Care Foods

Health care food, as a specific type of food, can regulate the function of human body, and is suitable for specific people. However, the phenomena of adding chemical drugs and illegal additives in health care food are endless. Therefore, it is urgent to set up an effective detection method with multiple indicators to provide technical guarantee for the quality and safety of health care food. Efficient sample pretreatment as well as sensitive analytical method are very important for the detection of illegal additives. The applications of pretreatment methods such as solvent extraction, solid phase extraction (SPE), and analytical methods including high performance liquid chromatography (HPLC), direct analysis in real time (DART-MS), surface-enhanced raman spectroscopy (SERS) and its tandem technique in the detection of trace illegal additives in recent three years are reviewed. A theoretical reference for the further research and establishment of efficient and simple pretreatment methods, new detection methods and technologies is provided.