SYNTHESIS AND DRUG RELEASE OF CROSSLINKING POLYPHOSPHATES

A new class of crosslinking polyphosphates were synthesized and characterized by IR ^1HNMR,^31PNMR spectroscopy as well as elemental analysis.In vitro degradation of the polyphosphates obtained and the release of antineoplastic drug Methotrexate(MTX) and contraceptive Levonorgestrel(LNG) by using these polymers as matrix were studied.Zero order release rate was observed in the case of LNG release.