Factors affecting drug adsorption on beta zeolites |
| |
Authors: | Luisa Pasti Elena Sarti Alberto Cavazzini Nicola Marchetti Francesco Dondi Annalisa Martucci |
| |
Institution: | 1. Department of Chemistry and Pharmaceutical Sciences, University of Ferrara, , Ferrara, Italy;2. Terra&AcquaTech Laboratory, University of Ferrara, , Ferrara, Italy;3. Physics and Earth Sciences Department, University of Ferrara, , Ferrara, Italy |
| |
Abstract: | The adsorption behaviour of three commonly used drugs, namely ketoprofen, hydrochlorothiazide and atenolol, from diluted aqueous solutions on beta zeolites with different SiO2/Al2O3 ratio (i.e. 25, 38 and 360) was investigated by changing the ionic strength and the pH, before and after thermal treatment of the adsorbents. The selective adsorption of drugs was confirmed by thermogravimetry and X‐ray diffraction. The adsorption capacity of beta zeolites was strongly dependent on both the solution pH and the alumina content of the adsorbent. Such a remarkable difference was interpreted as a function of the interactions between drug molecules and zeolite surface functional groups. Atenolol was readily adsorbed on the less hydrophobic zeolite, under pH conditions in which electrostatic interactions were predominant. On the other hand, ketoprofen adsorption was mainly driven by hydrophobic interactions. For undissociated molecules the adsorption capability increased with the increase of hydrophobicity. |
| |
Keywords: | Adsorption selectivity Beta zeolites Pharmaceuticals enrichment |
|
|