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Resolving power in liquid chromatography: A trade‐off between efficiency and analysis time
Authors:Jos Luís Dores‐Sousa  Jelle De Vos  Sebastiaan Eeltink
Institution:José Luís Dores‐Sousa,Jelle De Vos,Sebastiaan Eeltink
Abstract:This review describes chromatographic dispersion and different plate‐height models frequently used to assess the chromatographic performance of ultra‐high‐pressure liquid chromatography column technology. Furthermore, different performance indices, including the resolution, the separation impedance, and kinetic plots are discussed allowing to quantify and visualize the resolving power in liquid chromatography. The construction of kinetic plots is explained, and different visualization approaches are highlighted. Finally, key instrument and column‐technology developments to advance the kinetic performance limits are discussed and selected state‐of‐the‐art applications are highlighted.
Keywords:kinetic performance  kinetic plot  ultra high performance liquid chromatography  ultra high pressure liquid chromatography  van Deemter curve
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