Institution: | 1. College of Chemistry and Pharmacy, Northwest A&F University, Yangling, P. R. China
Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing, P. R. China
Key Laboratory of Food Quality and Safety for State Market Regulation, Beijing, P. R. China;2. College of Chemistry and Pharmacy, Northwest A&F University, Yangling, P. R. China;3. Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing, P. R. China
Key Laboratory of Food Quality and Safety for State Market Regulation, Beijing, P. R. China;4. Institute of Food Safety, Chinese Academy of Inspection and Quarantine, Beijing, P. R. China |
Abstract: | A novel magnetic covalent organic framework was synthesized via a one-step coating approach with solvothermal reaction employing 2,4,6-tris(4-aminophen-yl)-1,3,5-triazine and 2,4,6-triformylphloroglucinol as two building blocks by covalent bonding. The prepared magnetic covalent organic frameworks were properly characterized by different techniques and employed as adsorbents of magnetic solid-phase extraction. An analytical method was developed for the simultaneous determination of five fungicides in two Chinese herbal medicine samples via magnetic solid-phase extraction coupled to ultra high performance liquid chromatography with tandem mass spectrometry analysis. Under optimized magnetic solid-phase extraction conditions, the method exhibited satisfactory recoveries (74.0?109.6%) with relative standard deviations of 0.4?4.6%, low limits of detection (0.003?0.015 μg/kg), and good linearity (R2 > 0.9960). Compared with the traditional extraction method, the proposed method required a lower amount of adsorbent (3 mg) and extraction time (5 min). The adsorbent also had favorable reusability (not less than eight times). Therefore, the magnetic covalent organic frameworks could be a promising adsorbent for the extraction and quantitation of fungicides in Chinese herbal medicines. |