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Dual channel detection–diode array and mass spectroscopy (El or Cl)–in HPLC |
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| Authors: | P Sandra P Courselle G Steenbeke M Schelfaut |
| Abstract: | Simultaneous recording of UV and mass spectra (electron impact or chemical Ionization) in conventional HPLC is described. The LC eluent is divided into two parts; one is directed into a diode array detector and the other is introduced into the mass spectrometer via a particle beam interface. The analysis of the steroid esters of a pharmaceutical formulation illustrates the possibilities of dual channel (DAD-MS) HPLC detection. |
| Keywords: | High Performance Liquid Chromatography HPLC Dual channel detection Diode array Mass spectroscopy Electron Impact (El) or Chemical Ionization (Cl) |