Modified GC-phases for the enantiomeric separation of optically active compounds: Crosslinking experiments with polymeric chiral compounds |
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Authors: | G Schomburg I Benecke G Severin |
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Abstract: | Crosslinking experiments for immobilization of the well-known chiral stationary phases XE 60-L -valine-(S)- and XE 60-L -valine-(R)-α-phenylethylamide within capillary columns have been successfully carried out. Crosslinking was also obtained with mixtures of the chiral compound acrylyl-L -valine-(S)-α-phenylethylamide and the polyethylene glycol Carbowax 20M. Immobilization of 75% to 90% was achieved by crosslinking the polymeric chiral phases, but sometimes up to 100% of these phases remained within the columns after the usual subsequent solvent treatment. The crosslinking of Carbowax 20M with acrylyl-L -valine-(S)-α-phenylethylamide led to a chiral polymer of a polarity different from that of the common siloxane type chiral phases. |
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Keywords: | Gas chromatography GC Capillary columns Crosslinking Enantiomeric separation Polymeric chiral phases Polysiloxane skeleton Polyethylene glycol skeleton |
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