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A new facile approach to N-alkylpyrroles from direct redox reaction of 4-hydroxy-l-proline with aldehydes |
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| Authors: | ZhiQin Zou ZeJun Deng XinHong Yu ManMan Zhang SiHan Zhao Ting Luo Xin Yin Hui Xu Wei Wang |
| Institution: | 1. School of Pharmacy, Easy China University of Science & Technology, Shanghai, 200237, China 2. Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, NM, 87131, USA |
| Abstract: | An unprecedented acetic acid-catalyzed efficient access to N-alkylpyrroles from reaction of 4-hydroxy-l-proline with a variety of aldehydes has been achieved in good to excellent yields under mild reaction conditions. |
| Keywords: | aromatization decarboxylation enamines iminium redox isomerization |
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