Polyfluorene based conjugated polymer nanoparticles for two-photon live cell imaging |
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| Authors: | Shuang Li Xiao-Fang Jiang Qing-Hua Xu |
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| Institution: | 1.Institute of Polymer Optoelectronic Materials and Devices, State Key Laboratory of Luminescent Materials and Devices,South China University of Technology,Guangzhou,China;2.National University of Singapore (Suzhou) Research Institute,Suzhou,China;3.Department of Chemistry,National University of Singapore,Singapore,Singapore |
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| Abstract: | Two-photon excitation microscopy (2PEM) has been known as a noninvasive and powerful bio-imaging tool for studying living cells, intact tissues and living animals because of their unique advantages such as localized excitation, deep tissue penetration as well as less photo-damage. However, the major limitations that hinder its practical applications in biological systems are low two-photon absorption cross sections of conventional fluorescence probes. Conjugated polymer nanoparticles (CPNs) consisting of highly fluorescent conjugated polymers are promising fluorescent probes for 2PEM due to their unique advantages including large two-photon absorption cross sections, high fluorescence quantum yield, good photo-stability and biocompatibility, facile chemical synthesis, tunable optical properties as well as versatile surface modifications. This account summarizes the recent efforts of our group on development of novel polyfluorene based CPNs as 2PEM contrast agents for live cell imaging. |
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