Determination of ionization constant (pKa) and octanol-water partition coefficient (Log P) of cyclopiazonic acid |
| |
| Authors: | Sobolev Victor S |
| |
| Institution: | U.S. Department of Agriculture, Agricultural Research Service, National Peanut Research Laboratory, P.O. Box 509, Dawson, GA 39842, USA. vsobolev@nprl.usda.gov |
| |
| Abstract: | The ionization constant (pKa) and the octanol-water partition coefficient (log P) of the important mycotoxin cyclopiazonic acid (CPA) were determined by means of potentiometric titration, and the lipophilicity profile (log D) was calculated. Under the experimental conditions, pKa of CPA = 2.97 +/- 0.09, log P = 3.83 +/- 0.10, and log D at pH 7.4 = -0.58. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
