| 气相色谱-质谱法同时筛检人血液中26种常见毒药物 |
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| 引用本文： | 林晓珊,黄晓兰,吴惠勤,马叶芬,黄芳,朱志鑫.气相色谱-质谱法同时筛检人血液中26种常见毒药物[J].分析试验室,2009,28(10). |
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| 作者姓名： | 林晓珊 黄晓兰 吴惠勤 马叶芬 黄芳 朱志鑫 |
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| 作者单位： | 中国广州分析测试中心,广东省化学危害应急检测重点实验室,广州,510070 |
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| 摘 要： | 建立了气相色谱-质谱法(GC-MS)同时快速筛检人血液中26种常见毒药物的新方法.通过对样品前处理方法的摸索及GC-MS分析条件的优化,采用磷酸盐缓冲液(pH 3.5)稀释血样后,乙醚萃取,分段选择离子监测(SIM)法鉴定,并用提取离子进一步验证,可以同时检测甲胺磷、毒鼠强、地西泮、尼可刹米、利多卡因、苯巴比妥、阿托品等7大类共26种常见毒药物,回收率大部分达80%～90%,检测限为0.01 mg/L.本法用色谱保留时间、质谱特征离子同时定性,消除了血液中复杂基体的干扰,适用于中毒患者血液的应急检测.
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| 关 键 词： | 气相色谱-质谱 选择离子检测 血液 快速 毒物 药物 |
Simultaneous determinations of twenty-six common drugs in human blood by GC-MS |
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| LIN Xiao-shan,HUANG Xiao-lan,WU Hui-qin,Ma Ye-fen,HUANG Fang,ZHU Zhi-xin.Simultaneous determinations of twenty-six common drugs in human blood by GC-MS[J].Chinese Journal of Analysis Laboratory,2009,28(10). |
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| Authors: | LIN Xiao-shan HUANG Xiao-lan WU Hui-qin Ma Ye-fen HUANG Fang ZHU Zhi-xin |
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| Institution: | China National Analysis Center;Guangdong Key Laboratory of Chemical Emergency Test;Guangzhou 510070 |
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| Abstract: | A new method was developed for simultaneous determinations of twenty-six common drugs in human blood by GC-MS.In this method,the conditions for extracting solvent and GC-MS were investigated and optimized.The blood was diluted by phosphate buffer solution(pH 3.5) and was extracted by ether,and then detected by selected ion monitoring mode(SIM) and validated by the characteristic ions.Twenty-six common drugs of seven sorts were detected,such as methamidophos,tetramine,diazepam,nikethamide,lidocaine,atropine ... |
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| Keywords: | Gas chromatography-mass spectrometry Selected ion monitoring Human blood Celerity Poisons Drugs |
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