| 采用液相色谱-串联质谱同时检测动物源性食品中胺苯醇类药物及其代谢产物 |
| |
| 引用本文： | 赵善贞,邓晓军,郭德华,樊祥,伊雄海,张旖,武巧彬.采用液相色谱-串联质谱同时检测动物源性食品中胺苯醇类药物及其代谢产物[J].分析试验室,2010,29(11). |
| |
| 作者姓名： | 赵善贞 邓晓军 郭德华 樊祥 伊雄海 张旖 武巧彬 |
| |
| 作者单位： | 1. 上海出入境检验检疫局,上海,200135
2. 上海海洋大学,上海,200090 |
| |
| 摘 要： | 建立了采用液相色谱-串联质谱(LC-MS/MS)同时测定动物源食品中氯霉素、甲砜霉素、氟苯尼考以及氟苯尼考胺残留量的方法。三类胺苯醇类药物及其代谢物用氨化乙酸乙酯(97+3v/v)提取,C18小柱净化;其中氯霉素、甲砜霉素、氟苯尼考用内标法定量,氟苯尼考与氟苯尼考胺用外表法定量。方法的定量测定低限氯霉素为0.1μg/kg,甲氟霉素、氟苯尼考胺为1.00g/kg,各基质的加标平均回收率在73.8%～120.5%之间,相对标准偏差≤25%。
|
| 关 键 词： | 液相色谱-串联质谱 氯霉素 甲砜霉素 氟苯尼考 氟苯尼考胺 动物源性食品 |
Determination of amphemicols and their metabolite residues in foodstuffs of animal origin by liquid chromatography tandem mass spectrometry |
| |
| ZHAO Shan-zhen,DENG Xiao-jun,GUO De-hua,FAN Xiang,YI Xiong-hai,ZHANG Yi,WU Qiao-bin.Determination of amphemicols and their metabolite residues in foodstuffs of animal origin by liquid chromatography tandem mass spectrometry[J].Chinese Journal of Analysis Laboratory,2010,29(11). |
| |
| Authors: | ZHAO Shan-zhen DENG Xiao-jun GUO De-hua FAN Xiang YI Xiong-hai ZHANG Yi WU Qiao-bin |
| |
| Institution: | ZHAO Shan-zhen1,DENG Xiao-jun1,GUO De-hua1,FAN Xiang1,YI Xiong-hai1,ZHANG Yi1 and WU Qiaobin2 (1.Shanghai Entry-exit Inspection & Quarantine Bureau,Shanghai 200135,2.Shanghai Ocean University shanghai 200090) |
| |
| Abstract: | This paper presented a liquid chromatography tandem mass spectrometric (LC-MS/MS) method for the determination of Chloramphenico1 Thiamphenicol,Florfenicol and its metabolite residue Florfenicol Amine in food stuffs of animal origin.The residues were extracted by ethyl acetate+ammonium hydroxide (97+3 v/v) and cleaned up on C18 solid phase extraction column.These amphemicols and metabolite residue were determined by LC-MS/MS,Chloramphenico1,Thiamphenicol and Florfenicol were quantified by labelled correspon... |
| |
| Keywords: | LC-MS/MS Chloramphenico1 Thiamphenicol Florfenicol Florfenicol Amine Foodstuffs of Animal Origin |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
