Preparation and application of novel polymer nanoparticles in the detection of copper ion and cysteineEI北大核心CSCD

A novel amphiphilic copolymer，dipropenoxystyrene anthracene and acrylic acid copolymer（BASA-AA） was designed and synthesized based on divinyl anthracene. The polymer self-assembled rapidly in water to create polymer nanoparticles（BASA-AA NPs）with a uniform size of 45 nm，no dye leakage，and great brightness（Φ= 36%）. Because of the enormous number of carboxyl groups on the surface of the particles，it can disperse extremely well in water，and can be used for the rapid detection of copper ion and cysteine（Cys）in pure water， with the limit of detection of 45 nmol/L. The fluorescent intensity of the nanoparticles will be greatly reduced after the introduction of copper ion，realizing the detection of copper ion with high selectivity and sensitivity. A composite probe made of BASA-AA NPs and copper ion can detect Cys in the range of 0.1-10 µμmol/L，with the detection limit of 84 nmol/L，due to the high binding capacity of the sulfhydryl group and copper ion. The method is simple and rapid in material synthesis and preparation，and shows high selectivity and sensitivity in pure water. © 2023, Youke Publishing Co.,Ltd. All rights reserved.