| 高灵敏光学和电化学适配体传感器在真菌毒素快速检测中的研究进展 |
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| 引用本文： | 关凯仪,黄仁堂,张磊,王淑美.高灵敏光学和电化学适配体传感器在真菌毒素快速检测中的研究进展[J].分析试验室,2022,41(2):212-224. |
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| 作者姓名： | 关凯仪 黄仁堂 张磊 王淑美 |
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| 作者单位： | 广东药科大学中药学院,广州510006;国家中医药管理局中药数字化质量评价技术重点研究室,广东省中药质量工程技术研究中心,广州510006,国家中医药管理局中药数字化质量评价技术重点研究室,广东省中药质量工程技术研究中心,广州510006;广东药科大学药学院,广州510006 |
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| 基金项目： | 国家自然科学基金(81903798)； |
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| 摘 要： | 高灵敏的生物传感器在痕量真菌毒素污染的快速检测中备受关注.适配体除具有与抗体类似的高选择性外,还具有可体外合成和易修饰等独特优势,已成为现阶段生物传感器中常用的识别元件.随着指数富集的配体系统进化(SELEX)技术的发展,筛选获得的真菌毒素适配体越来越多,为不同真菌毒素的检测提供了基础条件,而适配体结合现代新型纳米材料...
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| 关 键 词： | 适配体 生物传感器 真菌毒素 纳米材料 |
A review on the advances of aptamer-based optical and electrochemical biosensors for rapid and sensitive detection of mycotoxins |
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| GUAN Kaiyi,HUANG Rentang,ZHANG Lei,WANG Shumei.A review on the advances of aptamer-based optical and electrochemical biosensors for rapid and sensitive detection of mycotoxins[J].Chinese Journal of Analysis Laboratory,2022,41(2):212-224. |
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| Authors: | GUAN Kaiyi HUANG Rentang ZHANG Lei WANG Shumei |
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| Institution: | (School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006;Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica of SATCM Engineering Technology Research Center for Chinese Materia Medica Quality of Guangdong Province,Guangzhou 510006;School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou 510006) |
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| Abstract: | Biosensors with higher sensitivity in rapid detection of trace mycotoxin contamination have attracted world attention.In addition to high selectivity similar to antibodies,aptamers also have unique advantages such as in vitro synthesis and easy modification,and have become commonly used identification elements in biosensors.With the development of the exponentially enriched ligand system evolution(SELEX)technology,more and more mycotoxin aptamers have been screened,providing basic conditions for the detection of different mycotoxins.In addition,the integration of aptamers and novel nanomaterials have extended the scope of biometric recognition and sensing in biosensing systems.In recent years,optical and electrochemical biosensors are quite fascinating detection modes for ultrasensitive screening of mycotoxin.Thus,this review summarized the principles,characteristics and the application progress of these two aptamer-based biosensors,as well as discussed the current problems and future prospect. |
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| Keywords: | aptamer biosensor mycotoxins nanoparticles |
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