固相萃取-液相色谱/质谱法同时测定食品中磺胺类人工合成甜味剂

采用超声波提取，阴离子交换固相萃取柱净化，液相色谱．质谱定量检测食品中3种磺胺类甜味剂。方法对固相萃取条件，包括提取溶剂、洗脱溶剂以及洗脱体积等条件进行了优化。方法对安赛蜜、糖精钠、甜蜜素的检出限低于10pg，平均回收率在88％以上。在0．01～50μg/mL范围内有良好的线性关系，相关系数大于0．9996。本方法可用于食品中磺胺类甜味剂的快速测定。

Solid phase extraction-liquid chromatography/mass spectrometry for simultaneous determination of artificial synthetic sulfa sweeteners in food

A rapid, simple and sensitive method for the simultaneous analysis of three sulfanilamide sweeteners in food was proposed. This method involved an ultrasonic extraction procedure followed by anion-exchange solid-phase extraction for clean-up, liquid chromatography-mass for spectrometry separation and detection. The conditions of solid phase extraction were optimized, including extraction solution, eluting solvent and elution volume. The detection limits and extraction recovery were below 10pg and above 88%, respectively. A good linear range from 0.01 to 50 kcg/mL with correlation coefficient of above 0. 9996 was also obtained. Because of wide quantitative range and accurate results, this method could be used for the rapid detection of sulfa sweeteners in food.