| 竹红菌素类光动力药物* |
| |
| 引用本文： | 刘岩岩,王雪松,张宝文.竹红菌素类光动力药物*[J].化学进展,2008,20(9):1345-1352. |
| |
| 作者姓名： | 刘岩岩 王雪松 张宝文 |
| |
| 作者单位： | （中国科学院理化技术研究所 北京 100080） |
| |
| 基金项目： | 中国科学院知识创新工程项目，国家自然科学基金 |
| |
| 摘 要： | 天然竹红菌素（包括竹红菌甲素和乙素）作为一种新型的光动力抗肿瘤药物，与血卟啉衍生物(HpD)相比，具有单一和确定的化学组成、易纯化、暗毒性低、兼具Type I和Type II双重敏化机制等优点。本文综述了竹红菌素类光敏剂在光动力疗法领域中近五年来的最新研究进展，包括竹红菌素的化学修饰、物理包裹、与生物大分子的相互作用以及动物细胞的体外和体内光动力性质研究，并对竹红菌素类光敏剂未来的研究方向作了展望。
|
| 关 键 词： | 光动力疗法 竹红菌素 化学修饰 物理包裹 生物大分子 |
| 收稿时间： | 2007-10-17 |
| 修稿时间： | 2007-11-27 |
Hypocrellin-Based Photodynamic Sensitizers |
| |
| Liu Yanyan,Wang Xuesong,Zhang Baowen.Hypocrellin-Based Photodynamic Sensitizers[J].Progress in Chemistry,2008,20(9):1345-1352. |
| |
| Authors: | Liu Yanyan Wang Xuesong Zhang Baowen |
| |
| Institution: | （Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China） |
| |
| Abstract: | As a new type of non-porphyrin photodynamic antitumor drugs, naturally occurring hypocrellins, including hypocrellin A (HA) and hypocrellin B (HB), present many advantages over hematoporphyrin derivative (HpD), such as single and definite chemical composition, ease in purification, low dark toxicity, dual sensitization mechanisms of Type I and Type II. In this paper, we review the development of hypocrellin-based photosensitizers in the field of photodynamic therapy (PDT) over the past five years, from chemical modification and physical encapsulation to interaction with biomolecules and photodynamic behaviors in vitro and in vivo of HA and HB. The future research directions for hypocrellin-based photosensitizers are also discussed. |
| |
| Keywords: | photodynamic therapy hypocrellin chemical modification physical encapsulation bio-marcromolecules |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《化学进展》浏览原始摘要信息 |
| 点击此处可从《化学进展》下载免费的PDF全文 |
|
