基于脱羧法的C—C键生成反应

羧酸和羧基功能基团广泛存在于各类有机化合物中。活泼的羧酸衍生物在功能团转换和构建C—C键方面占有十分重要的地位。含羧基的化合物具有价廉且易制备的特点,通过脱羧反应形成新的C—C键为有机合成反应提供了一条新的反应途径。脱羧反应具有高度的选择性并且主要副产物为二氧化碳,因此通过脱羧反应来构筑新的化学键的方法是一种廉价﹑环境友好的合成路线。关于脱羧反应的文献综述已经有很多,本文仅对过去几年中基于脱羧法的C—C键生成反应的研究进展做一简要综述。

Decarboxylative C-C Bond Formations

Carboxylic acid or carboxylate groups are among the most common functionalities in organic molecules. Activated derivatives of carboxylic acids have long served as versatile connection points in derivatizations and in the construction of carbon frameworks. Carboxylic acids are cheap and high availability. Decarboxylative reaction provides a new approach for organic synthesis. The carboxylic acid functionality ensures the regioselectivity of the reaction and only carbon dioxide is produced as waste. Thus decarboxylative reactions meet the requirement of green chemistry and its application in organic synthesis is very promising. Many reviews have been published on decarboxylative reactions. This review mainly focused on the progress of decarboxylative C-C bond formation during the past several years. Contents 
1 Introduction 
2 Decarboxylative cross-coupling reaction 
3 Decarboxylative Heck-type reaction 
4 Decarboxylative allylation 
5 Decarboxylative aldol and Mannich reaction 
6 Decarboxylative Claisen rearrangement reaction 
7 Decarboxylative addition 
8 Conclusions and outlook