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中药活性成分研究是中药现代化的重要组成部分
引用本文:朱大元.中药活性成分研究是中药现代化的重要组成部分[J].化学进展,2009,21(1):24-29.
作者姓名:朱大元
作者单位:中国科学院上海生命科学研究院上海药物研究所国家新药重点实验室
摘    要:中药现代化是一个逐步发展、不断完善和充实的长期的系统工程。中医药在我国民族生存和繁衍的几千年历程中起着至关重要的作用,具有自己的特色和优势,是中华民族的宝贵财富,既要继承,又要创新和发展。中药现代化可以有多种模式,只要有利于人民健康,有利于传承和发展中医药,不管采取何种模式均应得到鼓励和欢迎。中药的活性成分研究是中药现代化的重要组成部分:一方面,一些活性成分能直接或作为先导化合物间接发展成药物;另一方面,活性成分又为中药复方现代化提供物质基础。这体现在活性成分既在现代化中药的制造和生产中起到标准化作用,同时活性成分也是中药复方专利最重要的核心组成部分。

关 键 词:中医药  中药现代化  中药活性成分  新药研发  中药复方物质基础  中药标准化  专利保护
收稿时间:2008-10-20

Studies on Active Ingredients of TCM——The Essential Part of TCM's Modernization
Zhu Dayuan.Studies on Active Ingredients of TCM——The Essential Part of TCM''''s Modernization[J].Progress in Chemistry,2009,21(1):24-29.
Authors:Zhu Dayuan
Institution:(State Key Laboratory of New Drug, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China)
Abstract:The modernization of traditional Chinese medicine (TCM) is a long-period systematic project. TCM has a long history of serving Chinese people, which have been accumulated rich empirical knowledge of human clinical data on efficacy and toxicity in the treatment of diseases. TCM's modernization should admit multiform development with the prerequisite that will benefit the continuous development and improvement of TCM, as well as people's health care. The studies on the active ingredients of TCM is an essential part for TCM's modernization, which is embodied in (1) some active ingredients are directly used as drugs or as a lead compounds; (2) the active ingredients are not only the effective substances of TCM, but also important biomarkers for the standardization of modern TCM formula, whatever in the process of producing or final products. Furthermore, it should be the core competition of TCM patents. Contents
1 To develop directly new drugs using active TCM ingredients
2 To provide the material basis for TCM recipes
3 Biomarkers for modern TCM recipes’ preparation
4 Key role in patent application
Keywords:traditional Chinese medicine(TCM)  TCM's modernization  active ingredients of TCM  R&  D of new drug  substances of TCM  standardization of TCM  patent protection
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