| 序列特异性DNA断裂蛋白质 |
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| 引用本文： | 张若衡,王宏,徐筱杰.序列特异性DNA断裂蛋白质[J].化学进展,1994,6(1):14-25. |
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| 作者姓名： | 张若衡 王宏 徐筱杰 |
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| 作者单位： | 北京大学化学系 |
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| 摘 要： | 序列特异性DNA断裂蛋白质是在序列特异性DNA结合蛋白质及小分子DNA断裂试剂基础上设计合成的。其基本原理是在含有DN A结合域的蛋白质上引入一个金属鳌合剂并鳌合一个适当的金属离子，其中序列特异性DNA结合蛋白质具有与DNA特定序列结合的能力，从而可以起导向物的作用，而引入的金属鳌合齐J与金属离子复合物具有断裂DNA的功能，两者协同作用可以达到序列特异性断裂DNA的目的。
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| 关 键 词： | 序列特异性 DNA结合蛋白质 DNA断裂试剂 |
| 收稿时间： | 1994-01-04 |
Sequence-Specific DNA Cleaving Protein |
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| Zhang Ruoheng,Wang Hong,Xu Xiaojie.Sequence-Specific DNA Cleaving Protein[J].Progress in Chemistry,1994,6(1):14-25. |
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| Authors: | Zhang Ruoheng Wang Hong Xu Xiaojie |
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| Institution: | (Chemistry Department, Peking University, Beijing 100871, China) |
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| Abstract: | ased on the sequence-specific DNA-binding protein and DNA cleaving agents,complex of a chelator and an appropriate metal ion, sequence-specific DNA cleaving proteins were designed and synthesized. The DNA cleaving agents were directed to DNA by attachment to a DNA-binding protein, and the resulting protein may be used as a sequence-specific DNA cleaving protein. |
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| Keywords: | sequence-specific DNA-binding protein DNA cleaving agent |
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