| 金属在生物和医学中的作用 |
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| 引用本文： | 孙红哲,陈嵘,支志明.金属在生物和医学中的作用[J].化学进展,2002,14(4):257-262. |
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| 作者姓名： | 孙红哲 陈嵘 支志明 |
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| 作者单位： | 香港大学化学系和分子科技研究所化学生物学开放实验室,香港 |
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| 基金项目： | 香港研究资助局卓越研究领域 ( Area of Excellence)、香港大学和丽珠制药集团的资助 |
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| 摘 要： | 金属元素在整个生命体系中起着重要的作用。金属离子与核酸、蛋白质等生物大分子的作用以及对神经系统的不正常的影响可以直接或间接地损伤DNA从而引起细胞的变异，进而导致各种疾病；同时我们可以根据这些特性研究金属离子的药物用于各种疾病的诊断和治疗。本文着重介绍了几种重要的金属和无机药物。
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| 关 键 词： | 无机药物 疾病 金属 |
| 文章编号： | 1005-281X(2002)04-0257-06 |
Metals in Biology and Medicine |
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| Sun Hongzhe,Chen Rong,Che Chiming.Metals in Biology and Medicine[J].Progress in Chemistry,2002,14(4):257-262. |
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| Authors: | Sun Hongzhe Chen Rong Che Chiming |
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| Institution: | Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Snthesis, The University of Hong Kong, Hong kong |
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| Abstract: | Metals are necessary for normal function of cells and the survival of organisms. The abnormal interactions between metal ions and macromolecules (such as protein, DNA and RNA, etc.) and nerve system can damage DNA and cells, and hence cause diseases. Understanding of these interactions offers potentials for the discovery of novel therapeutic and diagnostic agents and also improves the knowledge about diseases that are currently intractable. Several metals and inorganic medicines are also reviewed. |
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| Keywords: | bioinorganic medicine diseases metals |
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