细胞无机化学中值得研究的问题*

在探索生命奥秘的过程中,生物无机化学研究由分子层次上升到细胞层次是一个必然的趋势,也是解决实际问题的需要.细胞无机化学研究在细胞生命体系中的无机化学反应和探索无机物对生命过程调节或干预的作用和机理,是探索生命体系复杂性研究的重要部分.细胞是保留完整生命活动特征的最小单位,存在周期、分化和受激等状态的不同.从化学的观点,细胞是一个严密设计的分子有序组装体,为一个多靶分子系统,细胞应答表现为由相关反应组合成的复杂过程.细胞无机化学研究包括无机物种在细胞膜上的结合和随后发生的膜结构和功能改变、跨细胞膜和跨生物组织屏障的转运和细胞代谢、细胞中无机化学反应同细胞信号系统的偶联、无机离子与自由基的相互代谢关系以及细胞-无机物固相的相互作用等方面.本文对当前细胞无机化学研究的重点问题进行了讨论.

The Important Topics in Inorganic Cytochemistry

For the purpose of exploring the complexity of life and solving the practical problems, study of chemical reactions on the cellular level is becoming a new trend in the field of biological chemical researches. Cell is the basic form of life, existing in a variety of states such as in different phases of cell cycle, under differentiation, and circumstantial stresses, etc. When encountering chemical compounds, a cell can be regarded as a deliberately designed assembly of all sorts of molecules and supermolecules with multiple targets; the cell response is a multi\|step complex chemical process comprising many specific reactions. Inorganic cytochemistry studies inorganic reactions inside cells and the mechanisms by which inorganic compounds regulate or interfere the cellular processes, including binding of inorganic species to the cell membrane and the effects on membrane structure, the cellular metabolism and transport of inorganic compounds across biological membranes and barriers, coupling of inorganic reactions with cellular signal transduction, the effects of inorganic species on metabolism of free radicals, and the interaction of cell with inorganic particles and solid surfaces. The current topics in inorganic cytochemical studies are discussed.