| 糖组学研究中糖蛋白糖链结构分析技术 |
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| 引用本文： | 孙兴权,李静,耿美玉,管华诗.糖组学研究中糖蛋白糖链结构分析技术[J].化学进展,2007,19(1):130-135. |
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| 作者姓名： | 孙兴权 李静 耿美玉 管华诗 |
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| 作者单位： | 中国海洋大学海洋药物与食品研究所,青岛,266003 |
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| 基金项目： | 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 遗传信息由DNA传递至蛋白质,再经蛋白质翻译后糖基化修饰形成糖蛋白.与DNA、蛋白质相比,糖蛋白糖链结构更加多样,功能更加复杂,在一些重大的生理、病理事件中发挥着重要调节作用;而糖链如此复杂的功能是由其多样的结构决定的,糖链结构是糖组学研究的重要内容.本文就近年来糖组学研究中糖蛋白样品的提取分离、糖链释放及结构分析的基本方法及相关技术进展作了简要介绍.
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| 关 键 词： | null |
| 文章编号： | 1005-281X（2007）01-0130-06 |
| 收稿时间： | 2006-03 |
| 修稿时间： | 2006-04 |
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| Sun Xingquan,Li Jing,Geng Meiyu,Guan Huashi.null[J].Progress in Chemistry,2007,19(1):130-135. |
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| Authors: | Sun Xingquan Li Jing Geng Meiyu Guan Huashi |
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| Institution: | Institute of Marine Drug and Food, Ocean University of China, Qingdao 266003, China |
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| Abstract: | Genetic information is transferred from DNA to protein and the protein is glycosylated subsequently, which results in the forming of glycoprotein. Comparing with DNA and protein, glycoprotein glycan possess more diverse structures and more complex functions which make the glycan play important regnlational roles in many significant physiological and pathological events. And the complex function of glycan attribute to its diverse structure which is one of the important content of glycomics. The recent research progress in analysis techniques and methods of extract and isolate glycoprotein from sample, release the glycan and identify its structure are introduced. |
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| Keywords: | glycomics system biology glycoprotein glycan isolation and purification structure study |
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