氮氧自由基TEMPO：选择氧化醇的高效有机小分子催化剂*

醇被氧化为相应的醛或酮是有机合成中重要的官能团转换反应之一。自从Anelli法（TEMPO/NaBr/NaOCl）发现以来，由于所具有的醇被氧化为相应的醛或酮是有机合成中重要的官能团转换反应之一。自从Anelli法（TEMPO/NaBr/NaOCl）发现以来，由于所具有的高活性和高选择性， 有机小分子催化剂2,2,6,6-四甲基哌啶-1-氧自由基(TEMPO)催化醇的氧化反应成为温和条件下醇选择氧化的一个重要方法，并在实验室和工业生产中广泛应用。最近有关TEMPO催化醇氧化反应的研究，主要集中在开发用于分子氧对醇绿色氧化的催化体系和目的在于实现催化剂回收再用的TEMPO固载化研究两个领域上。本文以此为重点，综述了TEMPO催化醇氧化反应的发展和最近研究进展。

Nitroxyl Radical TEMPO: An Organocatalyst for Highly Efficient and Selective Oxidation of Alcohol

The oxidation of alcohols to aldehydes or ketones is one of the fundamental transformation in organic synthesis.Since the Anelli's protocol(TEMPO/NaBr/NaOCl) is discovered,the oxidation of alcohol using TEMPO((2,2,6,6-)tetramethyl-piperidyl-1-oxyl) as an organocatalyst has become an important methodology under mild conditions due to its very high efficiency and selectivity,and is widely applied in both laboratory and industry.The recent researches on TEMPO-catalyzed oxidation of alcohol focused on two fields which are the investigation of catalytic systems for the green oxidation of alcohol with molecular oxygen as the terminal oxidant,and TEMPO immobilizations in order to realize recovery and recycling of the catalysts.With emphasis on the above two fields, the development and recent progress of TEMPO-catalyzed oxidation of alcohol is reviewed in this paper.