路易斯酸碱催化的外消旋体(动态)动力学拆分反应

外消旋体的(动态)动力学拆分反应是制备手性化合物的重要方法之一.反应可以通过酶催化或非酶催化的手段来实现,也可以通过两种方法的有机结合来进行.在非酶催化反应中,路易斯酸碱催化是比较常用的方法,它们被广泛地用于多种外消旋体的(动态)动力学拆分反应中,目前在该领域取得了很大的进展.本文讨论了路易斯酸及路易斯碱催化体系在外消旋体(动态)动力学拆分反应中应用的最新进展.

(Dynamic) Kinetic Resolution Reactions of Racemes Catalyzed by Lewis Acid and Base Catalysts

The (dynamic) kinetic resolution of raceme is one of the important ways in the synthesis of chiral compounds. The reaction can be realized by enzymatic or non-enzymatic catalysis or by combination of two methods. The catalytic systems of Lewis acid and base are useful ways in the non-enzymatic catalysis. They were widely used to different kinds of (dynamic) kinetic resolution reactions. At present, mighty advances have been made in the field.Recent progress in the applications of non-enzymatic system about Lewis acid and base to (dynamic)kinetic resolution reactions of racemes is reviewed.