Two new diterpenoids from the buds of Wikstroemia chamaedaphne |
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| Authors: | Guo Jieru Zhang Jinwen Shu Penghua Kong Lingmei Hao Xincai Xue Yongbo Luo Zengwei Li Yan Li Gao Yao Guangmin Zhang Yonghui |
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| Institution: | Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. |
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| Abstract: | Two new diterpenoids, wikstroelide Q (1) and prostratin Q (5), together with three known diterpenoids, pimelea factors P? (2), P? (3), and prostratin (4), and five known lignans, (+)-epipioresinol (6), (+)-isolariciresinol (7), (?)-lariciresinol (8), (+)-epi-sesaminone (9), and prestegane B (10), were isolated from the buds of Wikstroemia chamaedaphne Meissn. Their structures were elucidated by a combination of spectroscopic analyses. Compounds 1–10 were evaluated for their cytotoxicities against HL-60, SMMC-7721, A549, MCF-7, SW480, and BEAS-2B cell lines in vitro. |
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