Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe |
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| Authors: | Melissa M Cadelis Soeren Geese Benedict B Uy Daniel R Mulholland Shara J van de Pas Alex Grey Bevan S Weir Brent R Copp Siouxsie Wiles |
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| Institution: | 1.School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand;2.Bioluminescent Superbugs Lab, School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; (S.G.); (B.B.U.); (D.R.M.); (S.J.v.d.P.); (A.G.);3.Manaaki Whenua-Landcare Research, Private Bag 92170, Auckland 1142, New Zealand; |
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| Abstract: | Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2–5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL. |
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| Keywords: | antimicrobial natural product fungi MRSA naphthoquinone dimer |
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