New Bioactive Peptides Identified from a Tilapia Byproduct Hydrolysate Exerting Effects on DPP-IV Activity and Intestinal Hormones Regulation after Canine Gastrointestinal Simulated Digestion |
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| Authors: | Sandy Theysgeur Benoit Cudennec Barbara Deracinois Claire Perrin Isabelle Guiller Anne Lepoudre Christophe Flahaut Rozenn Ravallec |
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| Institution: | 1.UMR-T 1158, BioEcoAgro, University of Lille, F-59000 Lille, France; (S.T.); (B.D.); (C.F.);2.Diana Pet Food, F-56250 Elven, France; (C.P.); (I.G.); (A.L.);3.UMR Transfrontalière BioEcoAgro N° 1158, University of Artois, F-62000 Arras, France |
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| Abstract: | Like their owners, dogs and cats are more and more affected by overweight and obesity-related problems and interest in functional pet foods is growing sharply. Through numerous studies, fish protein hydrolysates have proved their worth to prevent and manage obesity-related comorbidities like diabetes. In this work, a human in vitro static simulated gastrointestinal digestion model was adapted to the dog which allowed us to demonstrate the promising effects of a tilapia byproduct hydrolysate on the regulation of food intake and glucose metabolism. Promising effects on intestinal hormones secretion and dipeptidyl peptidase IV (DPP-IV) inhibitory activity were evidenced. We identify new bioactive peptides able to stimulate cholecystokinin (CCK) and glucagon-like peptide 1 (GLP-1) secretions, and to inhibit the DPP-IV activity after a transport study through a Caco-2 cell monolayer. |
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| Keywords: | bioactive peptides in vitro gastrointestinal digestion fish byproduct hydrolysate cholecystokinin glucagon-like peptide 1 DPP-IV inhibitory peptides |
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