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Azaphenanthrene alkaloids with antitumoral activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae) |
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| Authors: | Lúcio Ana Silvia Suassuna Carneiro Almeida Jackson Roberto Guedes da Silva Barbosa-Filho José Maria Pita João Carlos Lima Rodrigues Branco Marianna Vieira Sobral Castello Diniz Margareth de Fátima Formiga Melo Agra Maria de Fátima da-Cunha Emidio V L da Silva Marcelo Sobral Tavares Josean Fechine |
| Institution: | Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Jo?o Pessoa, PB, Brazil. asilviasuassuna@gmail.com |
| Abstract: | Phytochemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith led to isolation of three azaphenanthrene alkaloids: eupolauramine, sampangine and imbiline 1. Their chemical structures were established on the basis of spectroscopic data from IR, HR-ESI-MS, NMR (including 2D experiments) and comparison with the literature. Sampangine and imbiline 1 are being described in the Anaxagorea genus for the first time. Eupolauramine and sampangine show concentration-dependent antitumoral activity in leukemic cells K562 with IC(50) of 18.97 and 10.95 μg/mL, respectively. |
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