Current Synthetic Routes to Peptidyl Mono-Fluoromethyl Ketones (FMKs) and Their Applications |
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| Authors: | Carissa M Lloyd Neil Colgin Steven L Cobb |
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| Institution: | 1.Department of Chemistry, Faculty of Science, Durham University, Durham DH1 3LE, UK;2.Cambridge Research Biochemicals, 17-18 Belasis Court, Belasis Hall Technology Park, Billingham, Cleveland TS23 4AZ, UK; |
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| Abstract: | Peptidyl mono-fluoromethyl ketones (FMKs) are a class of biologically active molecules that show potential as both protease inhibitors for the treatment of a range of diseases and as chemical probes for the interrogation of cellular processes. This review describes the current solid- and solution-phase routes employed for the synthesis of peptidyl mono-FMKs. In addition, it provides a brief overview of some of the key applications of FMKs in the fields of chemical biology and medicinal chemistry. |
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| Keywords: | peptide fluoromethyl ketone peptide synthesis peptide modification fluorine therapeutic probe |
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