(Poly)phenols in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Review |
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| Authors: | Marilyn Hagan Bu' Hussain Hayee Ana Rodriguez-Mateos |
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| Institution: | 1.Department of Nutrition and Dietetics, Royal Papworth Hospital NHS Foundation Trust, Cambridge CB2 0AY, UK;2.Department of Gastroenterology, King’s College Hospital NHS Foundation Trust, London SE5 9RS, UK;3.Department of Nutritional Sciences, Faculty of Life Sciences and Medicine, King’s College London, London WC2R 2LS, UK |
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| Abstract: | (Poly)phenols (PPs) may have a therapeutic benefit in gastrointestinal (GI) disorders, such as irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD). The aim of this review is to summarise the evidence-base in this regard. Observational evidence does not give a clear indication that PP intake has a preventative role for IBD or IBS, while interventional studies suggest these compounds may confer symptomatic and health-related quality of life improvements in known patients. There are inconsistent results for effects on markers of inflammation, but there are promising reports of endoscopic improvement. Work on the effects of PPs on intestinal permeability and oxidative stress is limited and therefore conclusions cannot be formed. Future work on the use of PPs in IBD and IBS will strengthen the understanding of clinical and mechanistic effects. |
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| Keywords: | inflammatory bowels disease (IBD) Crohn’ s disease ulcerative colitis irritable bowel syndrome (IBS) (poly)phenols |
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