Magnetization of individual yeast cells by in situ formation of iron oxide on cell surfaces |
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| Institution: | 1. Department of Chemistry Education, Korea National University of Education, Chungbuk 28173, South Korea;2. Center for Cell-Encapsulation Research, Department of Chemistry, KAIST, Daejoen 34141, South Korea;1. Department of Chemistry and Chemical Engineering, Jining University, Qufu, Shandong, 273155, China;2. Lunan Institute of Coal Chemical Engineering, Jining, 272000, China;1. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan;2. Grenoble Institute of Technology, CNRS UMR 5628, Laboratory of Materials and Physical Engineering, 3 Parvis L. Néel, 38016 Grenoble, France;3. From the School of Biological Sciences, Seoul National University, Building 504-421, Seoul 151-747, South Korea;4. the Center for Biomembrane Research, Department of Biochemistry and Biophysics, Stockholm University SE-106 91 Stockholm, Sweden;1. Key Laboratory of Food Processing Technology and Quality Control in Shandong Province, College of Food Science and Engineering, Shandong Agricultural University, Tai''an, 271000, PR China;2. College of Light Industry and Food Engineering, Guangxi University, Nanning, 530004, PR China |
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| Abstract: | Magnetic functionalization of living cells has intensively been investigated with the aim of various bioapplications such as selective separation, targeting, and localization of the cells by using an external magnetic field. However, the magnetism has not been introduced to individual living cells through the in situ chemical reactions because of harsh conditions required for synthesis of magnetic materials. In this work, magnetic iron oxide was formed on the surface of living cells by optimizing reactions conditions to be mild sufficiently enough to sustain cell viability. Specifically, the reactive LbL strategy led to formation of magnetically responsive yeast cells with iron oxide shells. This facile and direct post-magnetization method would be a useful tool for remote manipulation of living cells with magnetic interactions, which is an important technique for the integration of cell-based circuits and the isolation of cell in microfluidic devices. |
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