A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products |
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| Authors: | Vignesh Palani Melecio A Perea Kristen E Gardner Richmond Sarpong |
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| Institution: | Department of Chemistry, University of California, Berkeley California 94720 USA, |
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| Abstract: | The synthesis of diverse N-fused heterocycles, including the pyrido1,2-a]indole scaffold, using an efficient pyrone remodeling strategy is described. The pyrido1,2-a]indole core was demonstrated to be a versatile scaffold that can be site-selectively functionalized. The utility of this novel annulation strategy was showcased in a concise formal synthesis of three fascaplysin congeners.The synthesis of diverse N-fused heterocycles, including the pyrido1,2-a]indole scaffold, using an efficient pyrone remodeling strategy is described. |
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