The Syntheses and Characterization of Molecularly Imprinted Polymers for the Controlled Release of Bromhexine |
| |
Authors: | Saman Azodi-Deilami Majid Abdouss Mehran Javanbakht |
| |
Institution: | (1) Department of Chemistry, Amirkabir University of Technology, Tehran, Iran |
| |
Abstract: | Imprinted polymers are now being increasingly considered for active biomedical uses such as drug delivery. In this work, the
use of molecularly imprinted polymers (MIPs) in designing new drug delivery devices was studied. Imprinted polymers were prepared
from methacrylic acid (functional monomer), ethylene glycol dimethacrylate (cross-linker), and bromhexine (as a drug template)
using bulk polymerization method. The influence of the template/functional monomer proportion and pH on the achievement of
MIPs with pore cavities with a high enough affinity for the drug was investigated. The polymeric devices were further characterized
by FT-IR, thermogravimetric analysis, scanning electron microscopy, and binding experiments. The imprinted polymers showed
a higher affinity for bromhexine and a slower release rate than the non-imprinted polymers. The controlled release of bromhexine
from the prepared imprinted polymers was investigated through in vitro dissolution tests by measuring absorbance at λ
max of 310 nm by HPLC-UV. The dissolution media employed were hydrochloric acid at the pH level of 3.0 and phosphate buffers,
at pH levels of 6.0 and 8.0, maintained at 37.0 and 25.0 ± 0.5 °C. Results from the analyses showed the ability of MIP polymers
to control the release of bromhexine In all cases The imprinted polymers showed a higher affinity for bromhexine and a slower
release rate than the non-imprinted polymers. At the pH level of 3.0 and at the temperature of 25 °C, slower release of bromhexine
imprinted polymer occurred. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|