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Direct determination of 4-nitrobenzoyl chloride by high-performance liquid chromatography based on silanophilic interaction |
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| Authors: | Hongyan Li Qizhi Hu Xuequen Yang Zhiren Zhou |
| Institution: | a Central Laboratory, Xiangtan University, Hunan 411105, China b Department of Chemistry of Xiangtan University, Hunan 411105, China |
| Abstract: | A high-performance liquid chromatographic method without prederivatization was investigated for the direct determination of 4-nitrobenzoyl chloride and 4-nitrobenzoic acid. The separation was carried out on C3, C8 and C18 alkyl-bonded silica columns with cyclohexane-tetrahydrofuran as the eluent. The retention behaviour observed was obviously caused by the silanophilic interaction between the solute and stationary phase. Optimum separation of 4-nitrobenzoyl chloride and 4-nitrobenzoic acid was obtained on the C3 column and the calibration graph showed a significant linear relationship. The method was found to be quantitative, reproducible and rapid. |
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