Analysis of tobacco-specific N-nitrosamines in snuff by ethyl acetate extraction and liquid chromatography-tandem mass spectrometry |
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Authors: | Jansson Christer Paccou Alexandre Osterdahl Bengt-Göran |
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Institution: | Swedish National Food Administration, Research and Development Department, Box 622, SE-751 26 Uppsala, Sweden. chja@slv.se |
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Abstract: | A rapid, selective and sensitive method for routine analysis of the four tobacco-specific N-nitrosamines, N'-nitrosonornicotine, N'-nitrosoanatabine, N'-nitrosoanabasine and 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in snuff has been developed. The nitrosamines were isolated by ethyl acetate extraction and analysed by LC-MS-MS. Except for evaporation and filtration, no additional clean-up steps are needed in the proposed method. The detection limits for standard in solvent are between 0.0005 and 0.001 microg/ml (0.005 and 0.01 microg/g). |
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Keywords: | Tobacco Nitrosamines |
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