Comparing columns for gas chromatography with the two-parameter model for retention prediction |
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Authors: | Thewalim Yasar Sadiktsis Ioannis Colmsjö Anders |
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Institution: | Stockholm University, Department of Analytical Chemistry, SE-106 91 Stockholm, Sweden. |
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Abstract: | The retention times of selected compounds in temperature programmed gas chromatography were predicted using a two-parameter model, on the basis of thermodynamic data obtained from isothermal runs on seven capillary columns, primarily substituted with 5% diphenylsiloxane. The scope for using thermodynamic data obtained from isothermal runs on one column to optimize separation on a different column or a different instrument setup was investigated. Additionally, the predictive utility of thermodynamic data obtained using a DB-5 column that had been in use for three years was compared to that of a new column of the same model. It was found that satisfactory separation could be achieved on one capillary column or instrument setup on the basis of thermodynamic data obtained using a different column or instrument set-up. |
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Keywords: | Gas chromatography Prediction Retention time PCA score plot Aged column Thermodynamic properties |
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