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Preparation and Cytotoxicity of Poly(Methyl Methacrylate) Nanoparticles for Drug Encapsulation |
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| Authors: | Anderson N Mendes Isabela Hubber Mônica Siqueira Gleyce Moreno Barbosa Davyson de Lima Moreira Carla Holandino José Carlos Pinto Marcio Nele |
| Institution: | 1. Escola de Química, Universidade Federal do Rio de Janeiro;2. Escola de Química, Universidade Federal do Rio de Janeiro
Departamento de Produtos Naturais, Farmanguinhos/Fiocruz;3. Departamento de Produtos Naturais, Farmanguinhos/Fiocruz Faculdade de Farmácia, Universidade Federal do Rio de Janeiro;4. Faculdade de Farmácia, Universidade Federal do Rio de Janeiro;5. Departamento de Produtos Naturais, Farmanguinhos/Fiocruz;6. Programa de Engenharia Química da COPPE, Universidade Federal do Rio de Janeiro |
| Abstract: | Summary: This work aimed to produce poly(methyl methacrylate) nanoparticles for use in drug encapsulation. The polymer nanoparticles were produced using miniemulsion polymerization technique. Monomer miniemulsion showed moderate stability and polymer average particle size was about 90 nm. PMMA nanoparticles were tested for toxicity in human leukemic cell strain K562 and they did not show any adverse effect on cell viability. Therefore, poly(methyl methacrylate) nanoparticles are suitable to encapsulate antitumor agents. |
| Keywords: | biopolymers emulsion polymerization microencapsulation nanoparticles toxicity |