| 喹啉酮类化合物的合成及抗HIV活性研究进展 |
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| 引用本文： | 唐亚娟,严胜骄,林军.喹啉酮类化合物的合成及抗HIV活性研究进展[J].广州化学,2009,34(4):39-50. |
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| 作者姓名： | 唐亚娟 严胜骄 林军 |
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| 作者单位： | 云南大学,化学科学与工程学院,教育部自然资源药物化学重点实验室,云南,昆明,650091 |
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| 基金项目： | 国家自然科学基金，云南省自然科学基金(NO.2008CD063)项目 |
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| 摘 要： | 4-喹啉酮及其衍生物具有良好的抗病毒及抑制HIV-1整合酶活性。喹啉酮类化合物的合成研究成为抗HIV整合酶抑制剂研究开发的重要领域之一。文章着重从环合形成喹啉酮骨架的角度出发，综述了喹啉酮类化合物合成的最新进展，同时对其抗HIV活性作了简要介绍。
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| 关 键 词： | 4-喹啉酮 抗HIV 生物活性 |
Advances on the Synthesis and the Anti-HIV Activities of Quinolinones |
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| TANG Ya-juan,YAN Sheng-jiao,LIN Jun.Advances on the Synthesis and the Anti-HIV Activities of Quinolinones[J].Guangzhou Chemistry,2009,34(4):39-50. |
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| Authors: | TANG Ya-juan YAN Sheng-jiao LIN Jun |
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| Institution: | (Key Laboratory of Medicinal Chemistry for Natural Resource of Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China) |
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| Abstract: | 4-Quinolinone and its derivatives with specific anti-viral activity and inhibit integrase of HIV-1 activity. It is one of important field to research and develop anti-HIV integrase inhibitors on the basis of quinolinones. Based on the cyclization formation quinolinone skeleton, the recent progress in synthesis of quinolinones has been reviewed, while its anti-HIV activity is also briefly described. |
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| Keywords: | 4-quinolinone anti-HIV biological activity |
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