| 两亲嵌段共聚物聚乙二醇-聚谷氨酸苄酯纳米粒药物载体的合成研究 |
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| 引用本文： | 冯敏,潘仕荣,张静夏,王琴梅,吴伟荣,李瑞明.两亲嵌段共聚物聚乙二醇-聚谷氨酸苄酯纳米粒药物载体的合成研究[J].广州化学,2005,30(4):9-16. |
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| 作者姓名： | 冯敏 潘仕荣 张静夏 王琴梅 吴伟荣 李瑞明 |
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| 作者单位： | 1. 中山大学药学院,广东,广州,510089
2. 中山大学附属第一医院,广东,广州,510089 |
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| 摘 要： | 用磺酸酯法制备单端氨基聚乙二醇引发剂,引发谷氨酸苄酯羧酸酐开环聚合,生成可生物降解的两亲嵌段共聚物聚乙二醇﹣聚谷氨酸苄酯(PEG-PBLG),用IR,NMR和GPC表征了共聚物。用超微透析法制备PEG-PBLG聚合物纳米粒,荧光芘探针法测定纳米粒的临界聚集浓度(cac)。紫外分光光度计考察纳米粒对疏水性药物的增溶作用,PEG-PBLG可作为亚微粒药物输送系统的载体。
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| 关 键 词： | 聚乙二醇-聚谷氨酸苄酯 纳米粒 临界聚集浓度 |
| 文章编号： | 1009-220X(2005)04-0009-08 |
| 修稿时间： | 2004年10月9日 |
Synthesis and Characterization of PEG-PBLG Block Copolymer Nanoparticles as Drug Carriers |
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| FENG min,PAN Shi-rong,ZHANG Jin-xia,WANG Qin-mei,WU Wei-rong,LI Rui-ming.Synthesis and Characterization of PEG-PBLG Block Copolymer Nanoparticles as Drug Carriers[J].Guangzhou Chemistry,2005,30(4):9-16. |
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| Authors: | FENG min PAN Shi-rong ZHANG Jin-xia WANG Qin-mei WU Wei-rong LI Rui-ming |
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| Abstract: | The biodegradable block copolymer poly(ethylene glycol)-poly(γ-benzyle-L-glutamate)(PEG-PBLG) was synthesized by polymerization of γ-benzyle-L-glutamate-N-carboxyanhydride initiated with MePEG.Their structure and molecular weight were characterized by IR,NMR and GPC.The PEG-PBLG nanoparticles were prepared by diafiltration method.Solubilization was investigated by UV spectrophotometer;the critical aggregation concentration(cac) obtained by fluorescence spectroscopy. |
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| Keywords: | poly(ethylene glycol)-poly(γ-benzyle-L-glutamate) nanoparticles critical aggregation concentration |
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