Novel microwave synthesis of half‐sandwich [(η6‐C6H6)Ru] complexes and an evaluation of the biological activity and biochemical reactivity |
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| Authors: | Floyd A Beckford Alyssa Stott Antonio Gonzalez‐Sarrías Navindra P Seeram |
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| Institution: | 1. Science Division, Lyon College, , Batesville, AR, 72501 USA;2. Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, , Kingston, RI, 02881 USA |
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| Abstract: | We have used a novel microwave‐assisted method to synthesize a pair of half‐sandwich ruthenium–arene–thiosemicarbazone complexes of the type (η6‐C6H6Ru(TSC)Cl]PF6. The thiosemicarbazone (TSC) ligands are 2‐(anthracen‐9‐ylmethylene)hydrazinecarbothioamide and 2‐(anthracen‐9‐ylmethylene)‐N‐ethylhydrazinecarbothioamide derived from 9‐anthraldehyde. The complexes are moderately strong binders of DNA, with binding constants of 104 m ?1. They are also strong binders of human serum albumin, having binding constants of the order of 105 m ?1. The complexes show some in vitro anticancer activity against human colon cancer cells, Caco‐2 and HCT‐116, with positive therapeutic indices. They did not show any activity as antibacterial agents against the organisms that were studied. Copyright © 2013 John Wiley & Sons, Ltd. |
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| Keywords: | thiosemicarbazone organometallic |
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