Synthesis,X‐ray powder structure analysis and biological properties of a mononuclear Cu(II) complex of N‐2‐hydroxyhippuric acid |
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| Authors: | Soumya Basu Basab Chattopadhyay A Ganguly P Chakraborty P Roy Chowdhury S Samanta M Mukherjee A K Mukherjee S K Choudhuri |
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| Institution: | 1. Department of In‐vitro Carcinogenesis and Cellular Chemotherapy (IVCCC), Chittaranjan National Cancer Institute (CNCI), 37 S.P. Mukherjee Road, Calcutta‐700026, India;2. Department of Solid State Physics, Indian Association for the Cultivation of Science, Jadavpur, Kolkata‐700032, India;3. Chembiotek, Salt lake, Sector‐V, Calcutta‐700091, India;4. Department of Physics, Jadavpur University, Jadavpur, Kolkata‐700032, India |
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| Abstract: | A mononuclear copper (II) complex of N‐2‐hydroxyhippuric acid (2HHA), Cu(HA)(H2O)2], has been synthesized and characterized by spectroscopic and X‐ray powder diffraction studies. Crystal structure of Cu(HA)(H2O)2] reveals a distorted square‐pyramidal geometry around the metal center. The crystal packing in the complex exhibits a three‐dimensional framework formed by intermolecular O? ; H···O and C? H···O hydrogen bonds. Toxicity and antitumor properties of the complex have been studied in vivo. The complex, capable of depleting glutathione (GSH) at nontoxic doses, may be utilized to sensitize drug‐resistant cells where resistance is due to an elevated level of GSH. Copyright © 2009 John Wiley & Sons, Ltd. |
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| Keywords: | 2‐hydroxy hippuric acid (2HHA) copper (II) 2‐hydroxy hippurate dehydrate [Cu(HA)(H2O)2](CuHA) BSO Ehrlich ascites carcinoma powder diffraction structure analysis |
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